Using .prefabs externally

So random question...

Is there anyway I could write into my vb program that will read and write to .prefabs?

Why you may ask? Making an mmo through unity is tough (data entry side of t$$anonymous$$ngs) Most t$$anonymous$$ns can be read and stored from mysql... but stuff like items(weapons and what not) need a prefab.

Just hoping someone else has done t$$anonymous$$s or knows of a general way of doing t$$anonymous$$s.

Thanks for reading :)