Is there any problem with working with big units?

I'm making a 2D platformer. For the sprites, I've adjusted the "Pixels per Unit" to 1, so each pixel of the sprite is equivalent to 1 Unity-unit. This makes scripting much easier, because I can adjust the sprite to integer positions, and make sure that the pixels get perfectly alligned.

For seeing the whole scene, I have to zoom out quite a bit, and the same goes for the camera (size = 200 aprox). I don't have any level yet, but I guess they will be like 1000-2000 units long.

It works fine, but I'm wondering if this will have any effect on the game's performance or something...