Creating an asset bundle at runtime

As far as I know, the UnityEditor namespace isn't available in any built player. If you can find a way around that, and if that feature doesn't rely on any native Unity code that's stripped in a built player (or you can replace those features, somehow), then I suppose it's possible in theory. Seems like a long shot, though.

Asset bundles are usually platform-dependent. I don't know why generating them at runtime would change that.